Matrix Polymeric Excipients: Comparing a Novel Interpolyelectrolyte Complex with Hydroxypropylmethylcellulose
نویسندگان
چکیده
منابع مشابه
Preparation and characterization of a novel starch-based interpolyelectrolyte complex as matrix for controlled drug release.
A novel cationized starch-based interpolyelectrolyte complex (IPEC) was formed using kappa-carrageenan as the counter polyion. Characterization of the product by turbidity measurements and elemental analyses indicated a 1:1 interaction of the repeating units. FT-IR spectra for the IPEC showed some differences in comparison with either IPEC constituents or physical mixture. The swelling of table...
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Drug dosage forms contain many components in addition to the active pharmaceutical ingredient(s) to assist in the manufacturing process as well as to optimise drug delivery. Due to advances in drug delivery technology, excipients are currently included in novel dosage forms to fulfil specific functions and in some cases they directly or indirectly influence the extent and/or rate of drug releas...
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In this paper, we show that a matrix A in Mn(C) that has n coneigenvectors, where coneigenvaluesassociated with them are distinct, is condiagonalizable. And also show that if allconeigenvalues of conjugate-normal matrix A be real, then it is symmetric.
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Drug release from polymeric matrix systems is the rate-limiting step for drug bioavailability and is determined by drug solubility; most drugs show pH-dependent solubility. Polymeric matrices remain in the gastrointestinal tract for a longer period of time and are exposed to environments of varying pH, which can adversely affect drug release. In the present study, the pH-independent drug releas...
متن کاملDesigned hydrocolloid interpenetrating polymeric networks for clinical applications of novel drug-carrying matrix systems using Tris (6-isocyanatohexyl) isocyanurate and hydroxypropylmethylcellulose.
Hydroxypropyl methylcellulose (HPMC) was employed in this study to design controllable drug release systems because of its non-toxic nature, swelling properties. New interpenetrating polymer networks (IPN) of HPMC / tri-isocyanate crosslinked polyurethane (TCPU) could be prepared on the surfaces of IPN materials. To design "Novel Drug-carrying Matrix Systems", incorporation of novel structure i...
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ژورنال
عنوان ژورنال: Drug Delivery
سال: 2008
ISSN: 1071-7544,1521-0464
DOI: 10.1080/10717540801905009